People

Participating faculty with research interests in Molecular Signaling

The following faculty have indicated an interest in participating in a Center for Molecular Communication.  Most of these researchers are faculty on the Reynolda campus; WFUHS faculty are indicated by italics.

Rebecca Alexander, Professor of Chemistry, brings expertise in intramolecular signaling within proteins, with a focus on how conformational change is coupled to catalysis and how chemical events result in mechanical motion within proteins.

Edward Allen, Professor of Mathematics, contributes expertise in the application of combinatorial algorithms and computational algebraic modeling to problems in systems biology.

Peter Antinozzi, Assistant Professor of Biochemistry, examines the genetics and signaling of diabetes and other metabolic alterations.

Ulrich Bierbach, Professor of Chemistry designs structurally unique organic–inorganic hybrid molecules as pharmacophores for tackling chemoresistant disease and as probes of biomolecular structure and function.

Keith Bonin, Professor of Physics, is an expert in optics and optical system, and will work on imaging analysis and with optical (confocal) microscopy.

Heather Brown-Harding, Biology Department Assistant Director of Microscopy, contributes expertise in imaging, host-pathogen interactions, and cell cycle signaling.

Rong Chen, Assistant Professor of Physiology & Pharmacology investigates the function, trafficking and signaling of dopamine receptors and transporters in the brain following exposure to psychostimulants.

Samuel S. Cho, Associate Professor of Physics and Computer Science, is an expert on computational biophysics using  molecular dynamic simulations of protein and RNA folding and assembly mechanistic processes and their intramolecular signaling networks.

Lindsay Comstock-Ferguson, Associate Professor of Chemistry focuses on developing biochemical tools to study post-translational modifications by combining organic chemistry, biochemistry, and molecular biology.

James Curran, Professor of Biology, contributes expertise in the study of the molecular mechanism of genetic translation.

Larry Daniel, Professor of Biochemistry, is an expert on the signaling pathways that control cell growth and apoptosis.

Rajendar Deora, Associate Professor of Microbiology and Immunology has an active research program in the area of bacterial pathogenesis, regulation of bacterial gene expression and vaccine development.

Patricia C. Dos Santos, Associate Professor of Chemistry brings expertise on the biosynthesis of thio-cofactors and thiol-redox homeostasis in microbial systems. Her laboratory studies biosynthetic reactions involving sulfur trafficking and investigates metabolic and environmental conditions affecting these pathways in Bacillus species.

Susan Fahrbach, Reynolds Professor of Developmental Neurobiology and Professor of Biology, studies the hormonal controls of brain development in insect models.

Cristina M. Furdui, Associate Professor of Internal Medicine (WFUSM). Research is directed towards applying advanced systems biology methodologies to investigate the timing of signaling events in the propagation of receptor tyrosine kinase signaling under normal and pathogenic conditions. A second project is aimed at developing new nanokinetics platforms for quantitative monitoring of rapid enzyme kinetics and drug screening assays.

Matthew Fuxjager, Assistant Professor of Biology, studies the integration of steroid hormone signaling with studies of organismal behavior to better understand how these hormones act on group of cells to lead to adaptive shifts in animal performance.

Carole Gibson, Professor of Biology, contributes expertise in cell biology and advanced microscopy techniques for the localization of proteins within cells.

Martin Guthold, Professor of Physics, contributes expertise in the combination of atomic force microscopy (AFM) and fluorescence microscopy to image and determine the mechanical properties of biological samples.

Tom Hollis, Professor of Biochemistry addresses questions in nucleic acid metabolism and the processing of DNA to avoid activation of innate immune response using structural and biochemical techniques.

Allyn Howlett, Professor of Physiology and Pharmacology investigates cannabinoid receptors, G protein coupled receptors abundant in neurons and glia, utilizing cultured neuronal cells as our  model system. We investigate mechanisms of cAMP and phosphoCREB, CB1-Growth factor receptor (e.g. VEGF-FLK) trans-activation that mediates MAPK (ERK) phosphorylation, NO synthesis, guanylyl cyclase, and GPCR interacting proteins.

David John, Professor of Computer Science, contributes expertise on combinatorial algorithms, genetic algorithms, and computational algebraic modeling to the study of computational systems biology.

Erik Johnson, Associate Professor of Biology, contributes expertise in the use of the Drosophila melanogaster model system to study molecular physiology; he is an expert in the study of stress.

Daniel Kim-Shapiro, Professor of Physics contributes expertise on the use of biophysical tools to understand nitrogen oxide signaling and its mediation by hemoglobin and other proteins.

S. Bruce King, Professor of Chemistry, contributes expertise in organic chemistry, biochemistry and biophysics to better understand the roles of nitric oxide (NO) in biological systems.

George Kulik, Associate Professor of Cancer Biology explores the regulatory networks that control cell signaling pathways and the ways this knowledge can be utilized to improve cancer diagnosis and therapy.

Todd Lowther, Associate Professor of Biochemistry, investigates signaling relevant oxidative modifications of proteins and their repair pathways using both biochemical and structural (X-ray crystallographic) approaches.

Douglas Lyles, Professor and Chair of Biochemistry, has an active research program on the assembly of viral membranes and another on the suppression of host antiviral responses and the induction of apoptosis by viruses linked to cellular signal transduction associated with the induction of apoptosis.

Jed Macosko, Associate Professor of Physics, contributes expertise in the study of the mechanics of protein machines and motors using atomic force microscopy, single molecule fluorescence microscopy and video-enhanced differential interference contrast light microscopy.

Glen Marrs, Biology Department Director of Microscopy, contributes expertise in imaging methodology, neuroscience, and intercellular signaling at developing synapses.

Charles McCall, Professor of Internal and Molecular Medicine, research is with a long time focus on inflammation, currently developing the concept that redox signaling by nuclear a NAD- dependent Sirtuin 1 and 3 cysteine thiols determines acute inflammation outcome.

Gary Miller, Associate Professor of Health and Exercise Science examines hormone signals generated in clinical disease states, and how these are altered during the course of treatment of the conditions.

Lance D. Miller, Associate Professor of Cancer Biology, brings expertise in genomics and bioinformatics, with a focus on the transcriptional and genomic dynamics of human cancers and the discovery of genes with prognostic and mechanistic roles in cancer behavior.

Anthony J. A. Molina, Assistant Professor of Internal Medicine, examines the role of mitochondrial bioenergetics in aging and age-related diseases.  Our group contributes expertise in subcellular imaging and analysis of mitochondrial function.

Gloria Muday, Professor of Biology brings expertise on mechanisms that control the synthesis, secretion, and transport of both plant and mammalian hormones and how these coordinate complex physiological processes.

Kim Nelson, Instructor in Biochemistry studies the role of reactive oxygen species and cysteine oxidation in regulating protein function and cell signaling pathways. Mechanistic, structural and bioinformatic studies of the peroxiredoxin family of antioxidant proteins.

James Norris, Professor of Mathematics, is an expert in the development of statistical methodology for biological investigations.

John S. Parks, Professor of Pathology and Biochemistry, is studying inflammatory signaling in macrophages as a function of dietary fatty acid modification and ATP binding cassette transporter A1 (ABCA1) function in two projects.

James Pease, Assistant Professor of Biology, studies molecular evolution of speciation, adaptation, and hybridization with a focus on genomic analysis.

Snezana Petrović,  Assistant Professor of Physiology and Pharmacology studies proton and calcium-sensitive G protein-coupled receptors in epithelial cells and their role in regulation of vectorial, transepithelial ion transport using transgenic mouse models in conjunction with time-lapse ratiometric, FRET, and confocal imaging in microperfused kidney tubules isolated from transgenic mice

Leslie Poole, Professor of Biochemistry and Director of the Center for Structural Biology. The Poole laboratory contributes expertise in study of the control of redox-dependent signal transduction.

Wayne Pratt, Associate Professor of Psychology is an expert in the utilization of behavioral pharmacological methods to assess the role of brain reward circuitry in modulating feeding and appetitive behaviors in the rat.

Fred Salsbury, Associate Professor of Physics, is an expert on computational methods to study the relationships between macromolecular dynamics, structure and function.

Wayne Silver, Professor of Biology, is an expert in the study of the chemical senses.

Allen W. TsangAssistant Professor of Internal Medicine and Biochemistry, 1) understand how infection with a common sexually transmitted disease (STD)mediates tumor development and 2) use of natural compounds to reduce breast cancer risk.

William Turkett, Associate Professor of Computer Science, contributes expertise in the use of probabilistic and statistical machine learning approaches to gain insight into signaling mechanisms.

Pierre-Alexandre Vidi, Assistant Professor of Cancer Biology (WFUSM), examines how signaling from the cellular microenvironment influences nuclear organization and DNA repair in the context of breast cancer initiation and progression.

Mark E. Welker, William L. Poteat Professor of Chemistry works on synthesis and testing of prostate selective PI3Kinase/Akt Signaling Pathway Inhibitors.

Ke Zhang, Assistant professor of Biology, is an expert in non-coding RNAs mediated epigenetic regulation, chromosome biology and RNA quality control and Integrity

External Members

Manju Bhat, Associate Professor of Physiology at Winston-Salem State University, investigates the mechanisms of calcium signaling in sensory neurons and their modulation by anesthetics.

Richard Loeser Professor, Division of Rheumatology, Allergy and Immunology; Director of Basic and Translational Research, Thurston Arthritis Research Center, UNC, Chapel Hill. Contributes expertise in the investigation of intracellular signaling pathways in chondrocytes, with a focus on how arthritis, aging, and oxidative stress affect cell signaling.

Robert Newman, Assistant Professor of Biology, North Carolina A and T is interested in understanding the spatiotemporal regulation of cellular signal transduction, with a particular emphasis on phosphorylation-dependent signaling pathways developing genetically-targetable fluorescent biosensors to track the activities of specific kinases and phosphatases in the native cellular environment with high spatiotemporal resolution using live-cell fluorescence microscopy.

Andrew J. Wommack, Assistant Professor of Chemistry at High Point University, uses organic chemistry and biophysical techniques to study cysteine modifications in peptides and proteins by developing synthetic methods to install redox-inert disulfide bioistosteres.